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Putting the MD back into MDMA

A phase 3 study shows that MDMA may be a promising treatment for PTSD, which will require a shift in how this drug is perceived.

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Fig. 1: The brain pathways of PTSD and site of action of MDMA in therapy.


  1. Mitchell, J. M. et al. Nat. Med. (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Freudenmann, R. W., Oxler, F. & Bernschneider-Reif, S. Addiction 101, 1241–1245 (2006).

    Article  Google Scholar 

  3. Mithoefer, M. C. et al. J. Psychopharmacol. 25, 439–452 (2011).

    Article  CAS  Google Scholar 

  4. Sessa, B. et al. J. Psychopharmacol. 35, 375–383 (2021).

    Article  CAS  Google Scholar 

  5. Kuypers, K. P. et al. Psychopharmacology (Berl.) 235, 481–490 (2018).

    Article  CAS  Google Scholar 

  6. Nardou, R. et al. Nature 569, 116–120 (2019).

    Article  CAS  Google Scholar 

  7. Feduccia, A. A. & Mithoefer, M. C. Prog. Neuropsychopharmacol. Biol. Psychiatry 84, 221–228 (2018).

    Article  CAS  Google Scholar 

  8. Carhart-Harris, R. L. et al. Int. J. Neuropsychopharmacol. 1, 527–540 (2013).

    Google Scholar 

  9. Bedi, G., Phan, K. L., Angstadt, M. & de Wit, H. Psychopharmacology (Berl.) 207, 73–83 (2009).

    Article  CAS  Google Scholar 

  10. Carhart-Harris, R. L. et al. Biol. Psychiatry 78, 554–562 (2014).

    Article  Google Scholar 

  11. Hysek, C. M. et al. Soc. Cogn. Affect. Neurosci. 9, 1645–1652 (2014).

    Article  Google Scholar 

  12. Wardle, M. C. & de Wit, H. Psychopharmacology (Berl.) 231, 4219–4229 (2014).

    Article  CAS  Google Scholar 

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Correspondence to David J. Nutt.

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Competing interests

D.J.N. is a paid advisor to Awakn, a company with an interest in MDMA treatment research.

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Nutt, D.J., de Wit, H. Putting the MD back into MDMA. Nat Med 27, 950–951 (2021).

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