a, Heatmap showing the number of interactions in NEs pre-treatment, in Es pre-treatment, NEs on-treatment and Es on-treatment. b, Barplot showing for each cell-to-cell type interaction, the number of interactions shared and specific pre-treatment comparing Es versus NEs. c, Dotplot showing the significance (-log10 P value) and strength (mean value) of specific interactions between cancer cells and CD8+ T-cells comparing Es versus NEs. The aLb2 complex refers to ITGAL and ITGB2, which together form LFA-1 d, Difference in the number of significant CellPhoneDB interactions in Es comparing pre- versus on-treatment. e, Barplot showing per cell-to-cell type interactions, the number of interactions shared and specific in pre- versus on-treatment biopsies from Es. f, Dotplot showing the significance (-log10 P value) and strength (mean value) of specific interactions in Es between CD8+ T-cells and myeloid cells (either DCs, macrophages or monocytes) pre- versus on-treatment.