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Is presymptomatic ALS perivascular?

Increased activity in perivascular fibroblasts could precede motor-neuron degeneration and be a predictor of shorter survival in amyotrophic lateral sclerosis.

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Fig. 1: PVFs may contribute to early ALS pathogenesis.


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Correspondence to Timothy M. Miller.

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Competing interests

T.M.M. reports serving on the advisory board of Biogen, consulting for and a license agreement with Ionis Pharmaceuticals, consulting for Disarm Therapeutics and Cytokinetics, and a licensing agreement with C2N.

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Kreple, C.J., Schoch, K.M. & Miller, T.M. Is presymptomatic ALS perivascular?. Nat Med 27, 585–586 (2021).

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