Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

CANCER THERAPY

Androgen receptor agonists as breast cancer therapeutics

Nature Medicine volume 27, pages 198–199 (2021)Cite this article

Subjects

Models of estrogen receptor–positive breast cancer are used to explore the rationale for androgen receptor agonists as treatments for breast cancer.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: AR and ER signaling and crosstalk in breast cancer.

References

  1. Hickey, T.E. et al. Nat. Med. https://doi.org/10.1038/s41591-020-01168-7 (2020).

  2. Adair, F. E. & Herrmann, J. B. Ann. Surg. 123, 1023–1035 (1946).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Kelley, R. M. Cancer 28, 1686–1691 (1971).

    Article  CAS  PubMed  Google Scholar 

  4. Hu, R. et al. Clin. Cancer Res. 17, 1867–1874 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Vera-Badillo, F. E. et al. J. Natl. Cancer Inst. 106, djt319 (2014).

    Article  PubMed  Google Scholar 

  6. Palmieri, C. et al. San Antonio Breast Cancer Symposium https://www.abstractsonline.com/pp8/#!/9223/presentation/850 (2020).

  7. Michmerhuizen, A. R., Spratt, D. E., Pierce, L. J. & Speers, C. W. NPJ Breast Cancer 6, 47 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Krop, I. et al. Clin. Cancer Res. 26, 6149–6157 (2020).

    Article  CAS  PubMed  Google Scholar 

  9. Garay, J. P. & Park, B. H. Am. J. Cancer Res. 2, 434–445 (2012).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. D’Amato, N. C. et al. Mol. Cancer Res. 14, 1054–1067 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Schiff, R., Massarweh, S., Shou, J. & Osborne, C. K. Clin. Cancer Res. 9, 447S–454S (2003).

    CAS  PubMed  Google Scholar 

  12. Arruabarrena-Aristorena, A. et al. Cancer Cell (2020).

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA

    Jennifer L. Caswell-Jin & Christina Curtis

  2. Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA

    Christina Curtis

  3. Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA

    Christina Curtis

Authors
  1. Jennifer L. Caswell-Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christina Curtis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Jennifer L. Caswell-Jin or Christina Curtis.

Ethics declarations

Competing interests

C.C. has performed advisory board and/or consulting work for Genentech, GRAIL, Illumina and NanoString, and reports GRAIL stockholdings.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Caswell-Jin, J.L., Curtis, C. Androgen receptor agonists as breast cancer therapeutics. Nat Med 27, 198–199 (2021). https://doi.org/10.1038/s41591-021-01242-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41591-021-01242-8

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer