Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Entering the era of precision medicine in pediatric oncology

The Zero Childhood Cancer Program’s multi-platform sequencing approach identified molecular alterations in 94% of a cohort of 247 pediatric patients with high-risk cancers, which has enabled more-precise diagnoses and alternative therapeutic recommendations.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Key steps of ZERO.


  1. Steliarova-Foucher, E. et al. Lancet Oncol. 18, 719–731 (2017).

    Article  Google Scholar 

  2. Cunningham, R. M., Walton, M. A. & Carter, P. M. N. Engl. J. Med. 379, 2468–2475 (2018).

    Article  Google Scholar 

  3. Wong, M. Nat. Med. (2020).

  4. Capper, D. et al. Nature 555, 469–474 (2018).

    Article  CAS  Google Scholar 

  5. Vogelstein, B. et al. Science 339, 1546–1558 (2013).

    Article  CAS  Google Scholar 

  6. Gröbner, S. N. et al. Nature 555, 321–327 (2018).

    Article  Google Scholar 

  7. Schwartzentruber, J. et al. Nature 482, 226–231 (2012).

    Article  CAS  Google Scholar 

  8. Sturm, D. et al. Cell 164, 1060–1072 (2016).

    Article  CAS  Google Scholar 

  9. Sturm, D. et al. Cancer Cell 22, 425–437 (2012).

    Article  CAS  Google Scholar 

  10. Zhang, J. et al. N. Engl. J. Med. 373, 2336–2346 (2015).

    Article  CAS  Google Scholar 

  11. DuBois, S. G., Corson, L. B., Stegmaier, K. & Janeway, K. A. Science 363, 1175–1181 (2019).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Nada Jabado.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Hadjadj, D., Deshmukh, S. & Jabado, N. Entering the era of precision medicine in pediatric oncology. Nat Med 26, 1684–1685 (2020).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer