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Entering the era of precision medicine in pediatric oncology

Nature Medicine volume 26, pages 1684–1685 (2020)Cite this article

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The Zero Childhood Cancer Program’s multi-platform sequencing approach identified molecular alterations in 94% of a cohort of 247 pediatric patients with high-risk cancers, which has enabled more-precise diagnoses and alternative therapeutic recommendations.

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Fig. 1: Key steps of ZERO.

References

  1. Steliarova-Foucher, E. et al. Lancet Oncol. 18, 719–731 (2017).

    Article  Google Scholar 

  2. Cunningham, R. M., Walton, M. A. & Carter, P. M. N. Engl. J. Med. 379, 2468–2475 (2018).

    Article  Google Scholar 

  3. Wong, M. Nat. Med. https://doi.org/10.1038/s41591-020-1072-4 (2020).

  4. Capper, D. et al. Nature 555, 469–474 (2018).

    Article  CAS  Google Scholar 

  5. Vogelstein, B. et al. Science 339, 1546–1558 (2013).

    Article  CAS  Google Scholar 

  6. Gröbner, S. N. et al. Nature 555, 321–327 (2018).

    Article  Google Scholar 

  7. Schwartzentruber, J. et al. Nature 482, 226–231 (2012).

    Article  CAS  Google Scholar 

  8. Sturm, D. et al. Cell 164, 1060–1072 (2016).

    Article  CAS  Google Scholar 

  9. Sturm, D. et al. Cancer Cell 22, 425–437 (2012).

    Article  CAS  Google Scholar 

  10. Zhang, J. et al. N. Engl. J. Med. 373, 2336–2346 (2015).

    Article  CAS  Google Scholar 

  11. DuBois, S. G., Corson, L. B., Stegmaier, K. & Janeway, K. A. Science 363, 1175–1181 (2019).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Human Genetics, McGill University, Montreal, Canada

    Djihad Hadjadj & Nada Jabado

  2. Department of Experimental Medicine, McGill University, Montreal, Canada

    Shriya Deshmukh & Nada Jabado

  3. Department of Pediatrics, McGill University, Montreal, Canada

    Nada Jabado

  4. The Research Institute of the McGill University Health Centre, Montreal, Canada

    Nada Jabado

Authors
  1. Djihad Hadjadj
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  2. Shriya Deshmukh
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  3. Nada Jabado
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Corresponding author

Correspondence to Nada Jabado.

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The authors declare no competing interests.

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Hadjadj, D., Deshmukh, S. & Jabado, N. Entering the era of precision medicine in pediatric oncology. Nat Med 26, 1684–1685 (2020). https://doi.org/10.1038/s41591-020-1119-6

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