Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Treating cancer therapy–related cognitive impairment

Metformin can promote the regeneration of neural precursor cell populations and improve cognitive function in a preclinical model of cranial radiation and a pilot clinical study of children after cranial radiation and chemotherapy.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Use of metformin to treat NPC dysfunction after cancer therapy.


  1. Ayoub, R. et al. Nat. Med. (2020).

  2. Parent, J. M., Tada, E., Fike, J. R. & Lowenstein, D. H. J. Neurosci. 19, 4508–4519 (1999).

    Article  CAS  Google Scholar 

  3. Dietrich, J., Han, R., Yang, Y., Mayer-Pröschel, M. & Noble, M. J. Biol. 5, 22 (2006).

    Article  Google Scholar 

  4. Monje, M. L., Mizumatsu, S., Fike, J. R. & Palmer, T. D. Nat. Med. 8, 955–962 (2002).

    Article  CAS  Google Scholar 

  5. Monje, M. L., Toda, H. & Palmer, T. D. Science 302, 1760–1765 (2003).

    Article  CAS  Google Scholar 

  6. Gibson, E. M. et al. Cell 176, 43–55.e13 (2019).

    Article  CAS  Google Scholar 

  7. Geraghty, A. C. et al. Neuron 103, 250–265.e8 (2019).

    Article  CAS  Google Scholar 

  8. Armstrong, G. T. et al. J. Natl. Cancer Inst. 101, 946–958 (2009).

    Article  Google Scholar 

  9. Neumann, B. et al. Cell Stem Cell 25, 473–485.e8 (2019).

    Article  CAS  Google Scholar 

  10. Wang, J. et al. Cell Stem Cell 11, 23–35 (2012).

    Article  CAS  Google Scholar 

  11. Dadwal, P. et al. Stem Cell Reports 5, 166–173 (2015).

    Article  CAS  Google Scholar 

  12. Riggs, L. et al. Neuro-oncol. 19, 440–450 (2017).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Michelle Monje.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gibson, E.M., Monje, M. Treating cancer therapy–related cognitive impairment. Nat Med 26, 1174–1175 (2020).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer