Table 2 Predictors of hospitalization and severe respiratory illness for COVID-19

From: Determinants of COVID-19 disease severity in patients with cancer

VariableUnivariateMultivariate
OR (95% CI)P valueOR (95% CI)P value
Predictors of hospitalization, by logistic regression (n=411a)
Age (>65 years)1.81 (1.20–2.72)0.0041.53 (0.96–2.43)0.072
Sex (female)0.89 (0.60–1.32)0.575  
Race (non-white)1.36 (0.91–2.04)0.1351.62 (1.05–2.51)0.029
BMI (≥30 kg/m2)0.89 (0.58–1.36)0.585  
Smoking (current/former)1.60 (1.07–2.40)0.0221.37 (0.88–2.13)0.169
Asthma/COPD1.39 (0.81–2.37)0.2261.07 (0.59–1.92)0.828
Cancer (non-metastatic solid)1.00 (Ref)-1.00 (Ref) 
Cancer (metastatic solid)0.89 (0.53–1.50)0.6470.76 (0.43–1.34)0.338
Cancer (hematologic)2.24 (1.25–4.06)0.0072.49 (1.35–4.67)0.003
Major surgery (within 30 d)1.24 (0.53–2.84)0.612  
Diabetes1.20 (0.73–1.96)0.467  
Cardiac disorder1.86 (1.13–3.07)0.0151.35 (0.77–2.36)0.297
HTN/chronic kidney disease1.84 (1.24–2.75)0.0031.51 (0.96–2.39)0.077
Systemic chemotherapy (within 30 d)1.04 (0.70–1.54)0.845  
Chronic lymphopenia or corticosteroids1.86 (1.11–3.15)0.0191.85 (1.06–3.24)0.030
ICI2.53 (1.18–5.67)0.0172.84 (1.24–6.72)0.013
Predictors of severe respiratory illness, by Cox proportional hazard (n = 423)
VariableUnivariateMultivariate
HR (95% CI)P valueHR (95% CI)P value
Age (>65 years)2.02 (1.33–3.08)0.0011.67 (1.07–2.60)0.024
Sex (female)1.04 (0.68–1.58)0.859  
Race (non-white)1.20 (0.79–1.84)0.394  
BMI (≥30 kg/m2)1.01 (0.64–1.59)0.965  
Smoking (current/former)1.78 (1.17–2.72)0.0071.39 (0.89–2.17)0.148
Asthma/COPD1.63 (0.98–2.71)0.0591.24 (0.72–2.13)0.436
Cancer (non-metastatic solid)1.00 (Ref)-1.00 (Ref)-
Cancer (metastatic solid)0.87 (0.48–1.59)0.6580.75 (0.40–1.41)0.371
Cancer (hematologic)1.69 (0.92–3.10)0.0921.79 (0.97–3.32)0.063
Major surgery (within 30 d)1.31 (0.63–2.71)0.464  
Diabetes1.09 (0.65–1.83)0.745  
Cardiac disorder2.02 (1.28–3.19)0.0021.44 (0.88–2.37)0.147
HTN/chronic kidney disease1.68 (1.09–2.58)0.0201.18 (0.73–1.89)0.505
Systemic chemotherapy (within 30 d)1.19 (0.78–1.82)0.407  
Chronic lymphopenia or corticosteroids1.59 (0.97–2.59)0.0661.42 (0.86–2.34)0.165
ICI2.38 (1.29–4.38)0.0052.74 (1.37–5.46)0.004
  1. CI, confidence interval; COPD, chronic obstructive pulmonary disease; HTN, hypertension; HR, hazard ratio; OR, odds ratio.
  2. a12 patients were excluded from the hospitalization endpoint; they were already hospitalized for other reasons before testing positive for SARS-CoV-2 with RNA PCR testing.