Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

CELL THERAPY

Patching up hearts

Sci. Transl. Med. 12, eaat9683 (2020)

An off-the-shelf synthetic cardiac patch promotes cardiac recovery in a rat model of acute myocardial infarction.

Myocardial infarction frequently leads to permanent arrhythmias and heart failure due to the remodeling process after these events. Cell therapy has been proposed as a means whereby more permanent damage could be avoided; however, it suffers from drawbacks such as cells being ‘washed away’ by the beating heart, immune incompatibility and high expense.

Huang et al. fabricated an artificial cardiac patch made of a porcine extracellular-matrix scaffold and synthetic cardiac stromal cells, which are encapsulated secreted human cardiac cellular factors. The patch withstood cryopreservation and supported cardiac recovery in a rat model of myocardial infarction. The cell-based patch thus shows promise for clinical translation.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Hannah Stower.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Stower, H. Patching up hearts. Nat Med 26, 649 (2020). https://doi.org/10.1038/s41591-020-0904-6

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing