a, Matrigel invasion by 1 × 105 mouse melanoma B16F10-TR-shApoe cells treated with the indicated recombinant proteins (n = 4 biologically independent samples; one tailed t-test). b, Trans-well recruitment of 1 × 105 human umbilical vein endothelial cells treated with the indicated recombinant proteins by 5 × 104 human melanoma MeWo-LM2 cells (n = 4 biologically independent samples; one tailed t-tests). Data in (a-b) are representative of three independent experiments. c, Blood vessel density in YUMM1.7 tumors from APOE2 and APOE4 mice (n = 8 and 9 mice for APOE2 and APOE4 groups, respectively; two-tailed Mann-Whitney test; box plots show median, first and third quartiles, and whiskers represent minimum and maximum values.). Images show representative sections (scale bar = 100 µm).