Extended Data Fig. 2: Immunoprofiling of the tumor microenvironment in APOE2 versus APOE4 mice. | Nature Medicine

Extended Data Fig. 2: Immunoprofiling of the tumor microenvironment in APOE2 versus APOE4 mice.

From: Common germline variants of the human APOE gene modulate melanoma progression and survival

Extended Data Fig. 2

a-b, Representative flow cytometry plots from two independent experiments demonstrating the gating strategy to identify major myeloid (a) and lymphoid (b) cell subsets in the tumor microenvironment. c-d, Proportion of monocytic Ly6C + (c) and dendritic cell (d) subsets in the immune microenvironment of YUMM1.7 tumors in APOE2 and APOE4 mice (n = 8 and 9 mice for APOE2 and APOE4, respectively; representative of two independent experiments). e, Intratumoral CD8 + T cell infiltration in YUMM1.7 tumors from APOE2 and APOE4 mice (n = 7 and 9 mice for APOE2 and APOE4 groups, respectively). Images show representative sections (scale bar = 100 µm). All P values are based on two-tailed t-tests. Box plots show median, first and third quartiles, and whiskers represent minimum and maximum values.

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