The box extends from the lower to upper quartile values of the data, with an orange line at the median. The whiskers show the 5th & 95th percentiles. For the left column, the statistics are calculated across patients, where patients with multiple scans per quarter are volumes averaged across these scans. For the right column the statistics for volume ch ange over 3 months were calculated on the difference for each patient between the mean volume for that quarter against the previous quarter. Volumes are calculated using the whole 2.3*6*6mm OCT volume.