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The physician-scientist, 75 years after Vannevar Bush–rethinking the ‘bench’ and ‘bedside’ dichotomy

Vannevar Bush enshrined the ‘basic’ and ‘applied’ research dichotomy on which much of science policy is still built 75 years later. However, it is time to assess whether this vision for science best serves the purposes of medical research and physician-scientists in the 21st century.

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  1. 1.

    Bush, V. Science, the Endless Frontier (United States Government Printing Office, 1945).

  2. 2.

    Rosenberg, L. E. J. Am. Med. Assoc. 300, 1208–1209 (2008).

    CAS  Article  Google Scholar 

  3. 3.

    Narayanamurti, V. & Odumosu, T. Cycles of Invention and Discovery (Harvard University Press, 2016).

  4. 4.

    Sarma, G. P., Levey, A. & Faundez, V. F1000 Res. 8, 2123 (2020).

    Article  Google Scholar 

  5. 5.

    Ching, X. et al. J. R. Soc. Interface (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  6. 6.

    Topol, E. Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again (Basic Books, 2019).

  7. 7.

    Moawad, H. Careers Beyond Clinical Medicine (Oxford University Press USA, 2013).

  8. 8.

    Roberts, S. F., Fischhoff, M. A., Sakowski, S. A. & Feldman, E. L. Acad. Med. 87, 266–270 (2012).

    Article  Google Scholar 

  9. 9.

    Sutton, J. & Killian, C. D. Acad. Med. 71, 454–459 (1996).

    CAS  Article  Google Scholar 

  10. 10.

    Daye, D., Patel, C. B., Ahn, J. & Nguyen, F. T. J. Clin. Invest. 125, 883–887 (2015).

    Article  Google Scholar 

  11. 11.

    Brass, L. F. & Akabas, M. H. JCI Insight 4, e133009 (2019).

    Article  Google Scholar 

Download references


We thank V. Narayanamurti for insightful discussions.

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Correspondence to Gopal P. Sarma.

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The authors declare no competing interests.

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Sarma, G.P., Levey, A. & Faundez, V. The physician-scientist, 75 years after Vannevar Bush–rethinking the ‘bench’ and ‘bedside’ dichotomy. Nat Med 26, 461–462 (2020).

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