Neoadjuvant immune-checkpoint blockade in resectable colon cancer

Neoadjuvant checkpoint blockade achieves deep or complete pathologic responses in patients with mismatch-repair-deficient and mismatch-repair-proficient early colon cancer.

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Fig. 1: Neoadjuvant CTLA-4–PD-1 blockade in colon cancer.


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Correspondence to George Coukos.

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Competing interests

G.C. has received grants or research support from or is co-investigator in clinical trials by BMS, Celgene, Boehringer Ingelheim, Roche, Iovance and Kite, and has received honoraria for consultations or presentations by Roche, Genentech, BMS, AstraZeneca, Sanofi-Aventis, Nextcure and GeneosTx.

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Coukos, G. Neoadjuvant immune-checkpoint blockade in resectable colon cancer. Nat Med 26, 473–474 (2020).

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