Nature 578, 82–93, 94–101, 102–111, 112–121, 122–128 & 129–136 (2020)

A worldwide consortium of scientists has carried out a collaborative analysis of the genomics of cancer, providing insights into cancer complexity.

Genomic sequencing can be especially informative to understanding cancer, since it allows the identification of mutations that might drive the cancer, along with the mechanisms by which they come about and, if RNA is sequenced, whether there are any resultant effects on gene expression.

The Pan-Cancer Analysis of Whole Genomes consortium analyzed over 2,600 tumors in 38 tissues and presented their results in six papers in Nature.