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NEURODEGENERATION

Another step forward in blood-based diagnostics for Alzheimer’s disease

Measurement of phosphorylated tau protein in blood plasma allows Alzheimer’s disease to be distinguished from other neurological diseases and may assist in disease detection during the prodromal stage.

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Fig. 1: p-tau181 can be used as a prognostic and confirmatory biomarker for AD.

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Correspondence to Randall J. Bateman.

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Competing interests

Washington University and R.J.B. have equity ownership interest in C2N Diagnostics and receive royalty income based on technology (blood plasma assay) licensed by Washington University to C2N Diagnostics, and R.J.B. receives income from C2N Diagnostics for serving on the scientific advisory board. Washington University has submitted the US provisional patent application ‘Plasma Based Methods for Detecting CNS Amyloid Deposition’ (co-inventor, R.J.B.) and the US non-provisional patent application ‘Methods of Diagnosing and Treating Based on Site-Specific Tau Phosphorylation’ (co-inventors, R.J.B. and N.R.B.).

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Bateman, R.J., Barthélemy, N.R. & Horie, K. Another step forward in blood-based diagnostics for Alzheimer’s disease. Nat Med 26, 314–316 (2020). https://doi.org/10.1038/s41591-020-0797-4

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