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PRECISION MEDICINE

A precision medicine–based strategy for a severe adverse drug reaction

Nature Medicine volume 26, pages 167–168 (2020)Cite this article

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Detailed single-cell RNA-sequencing analysis of skin and blood from a patient with DRESS, a severe adverse drug reaction, leads to a personalized, hypothesis-driven treatment.

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Fig. 1: Precision-medicine pipeline for severe adverse drug reactions in drug-induced hypersensitivity and DRESS.

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Author information

Authors and Affiliations

  1. Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO, USA

    Madison R. Mack & Brian S. Kim

  2. Department of Medicine, Division of Dermatology, Washington University School of Medicine, St. Louis, MO, USA

    Madison R. Mack & Brian S. Kim

  3. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA

    Brian S. Kim

Authors
  1. Madison R. Mack
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  2. Brian S. Kim
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Correspondence to Brian S. Kim.

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Competing interests

B.S.K. has served as a consultant for AbbVie, Concert Pharmaceuticals, Incyte, Menlo Therapeutics, and Pfizer; is the founder and chief scientific officer of Nuogen Pharma; and has participated in advisory boards for Cara Therapeutics, Celgene, Kiniksa Pharmaceuticals, Menlo Therapeutics, Regeneron Pharmaceuticals, Sanofi, and Theravance Biopharma.

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Mack, M.R., Kim, B.S. A precision medicine–based strategy for a severe adverse drug reaction. Nat Med 26, 167–168 (2020). https://doi.org/10.1038/s41591-020-0756-0

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