Extended Data Fig. 5: HIV-1 Gag-specific T cell responses in early rebounders with bNAb-resistant reservoir. | Nature Medicine

Extended Data Fig. 5: HIV-1 Gag-specific T cell responses in early rebounders with bNAb-resistant reservoir.

From: Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity

Extended Data Fig. 5

(a) Study participant demographics and baseline clinical data4. Hisp: Hispanic; cobi: cobicistat; EVG: elvitegravir; FTC: emtricitabine; TAF: tenofovir alafenamide fumarate; TDF: tenofovir disoproxil fumarate. All participants harboured clade B viruses. d0: day 0; dx: diagnosis; Scr: screening. (b) Levels of plasma HIV-1 RNA (black; left y axis) and serum concentration of 3BNC117 (red) and 10-1074 (blue, right y axis) in the 2 participants enrolled in the bNAb+ATI trial with early rebound due to bNAb-resistant reservoir4. (c) Net frequency of total cytokine+ CD8+ or CD4+ T cells after HIV-1 Gag stimulation in both individuals at weeks -2, 7 and 11 (9245), or weeks -2, 6 and 12 (9251).

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