Extended Data Fig. 3: Whole-cell patch clamp measurements from control and YOPD mDA cultures. | Nature Medicine

Extended Data Fig. 3: Whole-cell patch clamp measurements from control and YOPD mDA cultures.

From: iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates

Extended Data Fig. 3

(a) Capacitance is similar between control and YOPD. (b) No difference in resting membrane potential (RMP) is observed. (c) Voltage-gated sodium current density is decreased in YOPD compared to control. No difference is observed in either the (d) inwards rectifying potassium current density, or (e) delayed rectifier potassium current density. * denotes significance p = 0.018 two tailed t-test with Welch’s correction. Bar graphs represent mean, error bars represent standard deviation (s.d.).

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