Extended Data Fig. 7: Testing of additional Proteosomal inhibitors. | Nature Medicine

Extended Data Fig. 7: Testing of additional Proteosomal inhibitors.

From: iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates

Extended Data Fig. 7

(a) Western blot of D30 mDA cultures in the presence of indicated proteasomal inhibitors. Quantification of blots from multiple differentiations (n=4 CTR, n=4 PD) with each point representing a band intensity from a separate differentiation. (b) P53 one-way ANOVA with Tukey multiple comparisons test (F 17.53 DF 20 p=0.0005 CTR Lac p=0.0003 CTR Epox p=0.0009 PD Lac p=0.001 PD Epox). (c) α-Syn one-way ANOVA with Tukey multiple comparisons test (F 1.6 DF 20 p=0.0.21). Bar graphs represent mean, error bars represent standard deviation (s.d.).

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