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GENETICS

Paternal sperm DNA mosaicism and recurrence risk of autism in families

Nature Medicine volume 26, pages 26–28 (2020)Cite this article

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Sequencing of paternal sperm DNA allows the identification of male germline mosaicism and may assist with recurrence risk prediction of de novo genetic variants associated with autism in some families.

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Fig. 1: Male germline mosaicism can be used to assist the prediction of recurrence of autism within some families.

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Authors and Affiliations

  1. Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA

    Eric M. Morrow

  2. Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital, East Providence, RI, USA

    Eric M. Morrow

  3. Hassenfeld Child Health Innovation Institute, Brown University, Providence, RI, USA

    Eric M. Morrow

  4. Center for Translational Neuroscience, Robert J. and Nancy D. Carney Institute for Brain Science and Brown Institute for Translational Science, Brown University, Providence, RI, USA

    Eric M. Morrow

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  1. Eric M. Morrow
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Correspondence to Eric M. Morrow.

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The author declares no competing interests.

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Morrow, E.M. Paternal sperm DNA mosaicism and recurrence risk of autism in families. Nat Med 26, 26–28 (2020). https://doi.org/10.1038/s41591-019-0732-8

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