GENETICS

Paternal sperm DNA mosaicism and recurrence risk of autism in families

Sequencing of paternal sperm DNA allows the identification of male germline mosaicism and may assist with recurrence risk prediction of de novo genetic variants associated with autism in some families.

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Fig. 1: Male germline mosaicism can be used to assist the prediction of recurrence of autism within some families.

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Correspondence to Eric M. Morrow.

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Morrow, E.M. Paternal sperm DNA mosaicism and recurrence risk of autism in families. Nat Med 26, 26–28 (2020). https://doi.org/10.1038/s41591-019-0732-8

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