Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

GENETICS

Paternal sperm DNA mosaicism and recurrence risk of autism in families

Sequencing of paternal sperm DNA allows the identification of male germline mosaicism and may assist with recurrence risk prediction of de novo genetic variants associated with autism in some families.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: Male germline mosaicism can be used to assist the prediction of recurrence of autism within some families.

References

  1. Ramaswami, G. & Geschwind, D. H. Handb. Clin. Neurol. 147, 321–329 (2018).

    Article  PubMed  Google Scholar 

  2. Breuss, et al. Nat. Med. https://doi.org/10.1038/s41591-019-0711-0 (2019).

  3. Sebat, J. et al. Science 316, 445–449 (2007).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  4. Jónsson, H. et al. Nature 549, 519–522 (2017).

    Article  PubMed  Google Scholar 

  5. Kong, A. et al. Nature 488, 471–475 (2012).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Bernkopf, M. et al. Hum. Mutat. 38, 1360–1364 (2017).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  7. Hancarova, M. et al. Am. J. Med. Genet. A. 179, 2119–2123 (2019).

    CAS  Article  PubMed  Google Scholar 

  8. Wilbe, M. et al. Prenat. Diagn. 37, 1146–1154 (2017).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Eric M. Morrow.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Morrow, E.M. Paternal sperm DNA mosaicism and recurrence risk of autism in families. Nat Med 26, 26–28 (2020). https://doi.org/10.1038/s41591-019-0732-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41591-019-0732-8

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing