High-accuracy liquid biopsies

Ultra-deep sequencing of paired plasma-circulating free DNA and white blood cells allows the identification of tumor-derived somatic mutations with high accuracy by filtering out variants consistent with clonal hematopoiesis.

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Fig. 1: Ultra-deep sequencing of paired cfDNA and white blood cells to identify variant origin in a representative cancer patient.


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Correspondence to Beatriz Bellosillo.

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Competing interests

B.B. has received honoraria for a speaker, consultancy or advisory role from Astra-Zeneca, Biocartis, Merck Serono, Novartis, Qiagen, Hoffman–La Roche, ThermoFisher, Pfizer and Bristol-Myers Squibb. C.M. declares institutional research funding from Amgen, Bayer, Biocartis, BMS, Merck Serono, Roche, and Sanofi Aventis as well as advisory board or speaker fees from Amgen, Biocartis, Merck Serono, Roche, Symphogen, Guardant Health, Seattle Genetics and Sysmex.

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Bellosillo, B., Montagut, C. High-accuracy liquid biopsies. Nat Med 25, 1820–1821 (2019).

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