Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

BIG DATA

Predicting health and life span with the deep plasma proteome

Recent large-scale proteomic studies reveal the association of levels of circulating proteins with life span and many health-related outcomes.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Proteomics measures for aging and health.

References

  1. Villeda, S. A. et al. Nature 477, 90–94 (2011).

    Article  CAS  Google Scholar 

  2. Conboy, I. M. et al. Nature 433, 760–764 (2005).

    Article  CAS  Google Scholar 

  3. Nakamura, A. et al. Nature 554, 249–254 (2018).

    Article  CAS  Google Scholar 

  4. Dodgson, S. E. Cell 173, 1–3 (2018).

    Article  CAS  Google Scholar 

  5. Cohen, J. D. et al. Science 359, 926–930 (2018).

    Article  CAS  Google Scholar 

  6. Emilsson, V. et al. Science 361, 769–773 (2018).

    Article  CAS  Google Scholar 

  7. Sun, B. B. et al. Nature 558, 73–79 (2018).

    Article  CAS  Google Scholar 

  8. Lehallier, B., Gate, D., Schaum, N. & Nanasi, T. Nat. Med. https://doi.org/10.1038/s41591-019-0673-2 (2019).

  9. Williams, S. A., Kivimaki, M., Langenberg, C. & Hingorani, A. D. Nat. Med. https://doi.org/10.1038/s41591-019-0665-2 (2019).

  10. Middeldorp, J. et al. JAMA Neurol. 73, 1325–1333 (2016).

    Article  Google Scholar 

  11. Sherman, R. E. et al. N. Engl. J. Med. 375, 2293–2297 (2016).

    Article  Google Scholar 

  12. Schadt, E. E. Nature 461, 218–223 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Valur Emilsson.

Ethics declarations

Competing interests

L.L.J. is an employee and stockholder of Novartis. V.E. and V.G. declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Emilsson, V., Gudnason, V. & Jennings, L.L. Predicting health and life span with the deep plasma proteome. Nat Med 25, 1815–1816 (2019). https://doi.org/10.1038/s41591-019-0677-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41591-019-0677-y

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing