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Predicting health and life span with the deep plasma proteome

Nature Medicine volume 25, pages 1815–1816 (2019)Cite this article

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Recent large-scale proteomic studies reveal the association of levels of circulating proteins with life span and many health-related outcomes.

Blood is uniquely tasked to mediate coordination between nonadjacent tissues via immune cells, metabolites and the vast number of proteins that circulate within it. Thus, studying the blood proteome offers opportunities to understand different organ systems and their communication and coordination in both health and disease. Furthermore, since blood can be collected in a minimally invasive manner, proteins can be broadly measured in plasma on a routine basis for individual health monitoring.

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Fig. 1: Proteomics measures for aging and health.

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Authors and Affiliations

  1. The Icelandic Heart Association, Kopavogur, Iceland

    Valur Emilsson & Vilmundur Gudnason

  2. Faculty of Medicine, University of Iceland, Reykjavik, Iceland

    Valur Emilsson & Vilmundur Gudnason

  3. Novartis Institutes for BioMedical Research, Cambridge, MA, USA

    Lori L. Jennings

Authors
  1. Valur Emilsson
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  2. Vilmundur Gudnason
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  3. Lori L. Jennings
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Corresponding author

Correspondence to Valur Emilsson.

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Competing interests

L.L.J. is an employee and stockholder of Novartis. V.E. and V.G. declare no competing interests.

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Emilsson, V., Gudnason, V. & Jennings, L.L. Predicting health and life span with the deep plasma proteome. Nat Med 25, 1815–1816 (2019). https://doi.org/10.1038/s41591-019-0677-y

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  • DOI: https://doi.org/10.1038/s41591-019-0677-y

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