SGLT-2 inhibitors in heart failure: a new therapeutic avenue

Dapagliflozin, a sodium-glucose co-transporter-2 inhibitor, reduced the risk of cardiovascular death or heart failure events in 4,744 patients with chronic heart failure with reduced ejection fraction.

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Fig. 1: A timeline of the discovery and evaluation of SGLT2 inhibitors.


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Correspondence to Javed Butler.

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Competing interests

M.V. is supported by the KL2/Catalyst Medical Research Investigator Training award from Harvard Catalyst (NIH/NCATS Award UL 1TR002541), serves on advisory boards for Amgen, AstraZeneca, Baxter Healthcare, Bayer AG, Boehringer Ingelheim and Relypsa, and participates on clinical endpoint committees for studies sponsored by Novartis and the NIH. J.B. has served as a consultant to Abbott, Amgen, Array, Applied Therapeutics, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, CVRx, G3 Pharma, Gilead, Impulse Dynamics, Innolife, Janssen, LivaNova, Luitpold, Medtronic, Merck, Novartis, NovoNordisk, Relypsa, Roche, Sanofi, V-Wave Limited and Vifor.

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Vaduganathan, M., Butler, J. SGLT-2 inhibitors in heart failure: a new therapeutic avenue. Nat Med 25, 1653–1654 (2019).

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