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Biomarkers for neoadjuvant checkpoint blockade response in urothelial cancer

Activated CD8+ T cells in the tumor and cytotoxic T cell signature correlate with immune response in patients receiving neoadjuvant immunotherapy for treatment of muscle invasive bladder cancer.

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Fig. 1: Immune biomarkers suggestive of response to neoadjuvant immunotherapy.


  1. Bellmunt, J. & Bajorin, D. F. N. Engl. J. Med. 376, 2304 (2017).

    Article  Google Scholar 

  2. Balar, A. V. et al. Lancet Oncol. 18, 1483–1492 (2017).

    Article  CAS  Google Scholar 

  3. Mariathasan, S. et al. Nature 554, 544–548 (2018).

    Article  CAS  Google Scholar 

  4. Teo, M.Y. et al. J. Clin. Oncol. JCO2017757740 (2018).

  5. Powles, T. et al. (2019).

  6. Necchi, A. et al. J. Clin. Oncol. JCO1801148 (2018).

  7. Hoimes, C. J et al. ESMO 2018 Congress, LBA33 (2018).

  8. Huang, A. C. et al. Nat. Med. 25, 454–461 (2019).

    Article  CAS  Google Scholar 

  9. Sjödahl, G. et al. Clin. Cancer Res. 18, 3377–3386 (2012).

    Article  Google Scholar 

  10. Ayers, M. et al. J. Clin. Invest. 127, 2930–2940 (2017).

    Article  Google Scholar 

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Correspondence to Elizabeth Plimack.

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Ghatalia, P., Plimack, E. Biomarkers for neoadjuvant checkpoint blockade response in urothelial cancer. Nat Med 25, 1650–1651 (2019).

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