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An Alzheimer’s-disease-protective APOE mutation

Homozygous APOE3-Christchurch (R136S) mutation protects a presenilin 1 (PSEN1) mutation carrier from developing Alzheimer’s disease until her seventies.

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Fig. 1: Effects of APOE3-R136S on Aβ and tau pathologies, neurodegeneration and cognition in PSEN1 mutation carriers, with potential underlying mechanisms.


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Correspondence to Yadong Huang.

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Y. H. is a cofounder and scientific advisory board member of E-Scape Bio, Inc. and GABAeron, Inc. The other authors declare no competing financial interests.

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Zalocusky, K.A., Nelson, M.R. & Huang, Y. An Alzheimer’s-disease-protective APOE mutation. Nat Med 25, 1648–1649 (2019).

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