Homozygous APOE3-Christchurch (R136S) mutation protects a presenilin 1 (PSEN1) mutation carrier from developing Alzheimer’s disease until her seventies.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Huang, Y. & Mucke, L. Cell 148, 1204–1222 (2012).
Quiroz, Y. T. et al. JAMA Neurol. 75, 548–556 (2018).
Acosta-Baena, N. et al. Lancet Neurol. 10, 213–220 (2011).
Arboleda-Velasquez, J. F. et al. Nat. Med. https://doi.org/10.1038/s41591-019-0611-3 (2019).
Mahley, R. W., Huang, Y. & Rall, S. C. Jr. J. Lipid Res. 40, 1933–1949 (1999).
Rauch, J. N. et al. Sci. Rep. 8, 6382 (2018).
Corder, E. H. et al. Science 261, 921–923 (1993).
Liu, C. C., Kanekiyo, T., Xu, H. & Bu, G. Nat. Rev. Neurol. 9, 106–118 (2013).
Wang, C. et al. Nat. Med. 24, 647–657 (2018).
Najm, R., Jones, E. A. & Huang, Y. Mol. Neurodegener. 14, 24 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
Y. H. is a cofounder and scientific advisory board member of E-Scape Bio, Inc. and GABAeron, Inc. The other authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Zalocusky, K.A., Nelson, M.R. & Huang, Y. An Alzheimer’s-disease-protective APOE mutation. Nat Med 25, 1648–1649 (2019). https://doi.org/10.1038/s41591-019-0634-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41591-019-0634-9
This article is cited by
-
Genetics of Alzheimer’s disease: an East Asian perspective
Journal of Human Genetics (2023)
-
The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation
Nature Neuroscience (2023)
-
Dissecting the clinical heterogeneity of early-onset Alzheimer’s disease
Molecular Psychiatry (2022)