Microneedle patch drug delivery in the gut

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A novel oral capsule can deploy microneedle patches that release drugs into the intestinal wall for uptake into the bloodstream as shown in animal studies, thereby avoiding injections.

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Fig. 1: Oral capsule for delivery of biologics via the intestine using microneedle patches.


  1. 1.

    Marcum, Z. A., Sevick, M. A. & Handler, S. M. JAMA 309, 2105–2106 (2013).

  2. 2.

    Rubin, R. R., Peyrot, M., Kruger, D. F. & Travis, L. B. Diabetes Educ. 35, 1014–1022 (2009).

  3. 3.

    Liu, C., Kou, Y., Zhang, X., Cheng, H., Chen, X. & Mao, S. Expert Opin. Drug Deliv. 15, 223–233 (2018).

  4. 4.

    Abramson, A. et al. Nat. Med. https://doi.org/10.1038/s41591-019-0598-9 (2019).

  5. 5.

    Homayun, B., Lin, X. T. & Choi, H. J. Pharmaceutics 11(3), 129 (2019).

  6. 6.

    Lipinski, C. A., Lombardo, F., Dominy, B. W. & Feeney, P. J. Adv. Drug Deliv. Rev. 23, 3–25 (1997).

  7. 7.

    Prausnitz, M. R. Annu. Rev. Chem. Biomol. 8, 177–200 (1997).

  8. 8.

    Bhatnagar, S., Dave, K. & Venuganti, V. V. K. J. Control. Release 260, 164–182 (2017).

  9. 9.

    Hou, A., Cohen, B., Haimovic, A. & Elbuluk, N. Dermatol. Surg. 43, 321–339 (2017).

  10. 10.

    Grover, N. Endpoints News https://endpts.com/robotic-pill-technology-found-to-be-safe-tolerable-in-early-human-study-paving-ground-for-oral-biologics/ (28 February 2019).

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Correspondence to Mark R. Prausnitz.

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Competing interests

M.P. is an inventor of patents that have been or may be licensed to companies developing microneedle-based products, is a paid advisor to companies developing microneedle-based products and is a founder/shareholder of companies developing microneedle-based products, including Micron Biomedical. These potential conflicts of interest have been disclosed and are being managed by Georgia Tech and/or Emory University.

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