Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

CANCER

Deciphering brain tumor heterogeneity, one cell at a time

Single-cell RNA sequencing characterizes clonal dynamics and distinct cellular states contributing to intratumoral heterogeneity in glioblastoma and medulloblastoma.

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Comprehensive profiling of intratumoral heterogeneity in aggressive brain cancers using scRNA-seq.

References

  1. 1.

    Turajlic, S., Sottoriva, A., Graham, T. & Swanton, C. Nat. Rev. Genet. 20, 404–416 (2019).

    CAS  Article  Google Scholar 

  2. 2.

    Suva, M. L. & Tirosh, I. Mol. Cell 75, 7–12 (2019).

    CAS  Article  Google Scholar 

  3. 3.

    Neftel, C. et al. Cell 178, 835–849 (2019).

    CAS  Article  Google Scholar 

  4. 4.

    Hovestadt, V. et al. Nature 572, 74–79 (2019).

    CAS  Article  Google Scholar 

  5. 5.

    Stupp, R. et al. N. Engl. J. Med. 352, 987–996 (2005).

    CAS  Article  Google Scholar 

  6. 6.

    Verhaak, R. G. et al. Cancer Cell 17, 98–110 (2010).

    CAS  Article  Google Scholar 

  7. 7.

    Wang, Q. et al. Cancer Cell 32, 42–56 e46 (2017).

    Article  Google Scholar 

  8. 8.

    Patel, A. P. et al. Science 344, 1396–1401 (2014).

    CAS  Article  Google Scholar 

  9. 9.

    Vladoiu, M. C. et al. Nature 572, 67–73 (2019).

    CAS  Article  Google Scholar 

  10. 10.

    Gao, R. et al. Nat. Commun. 8, 228 (2017).

    Article  Google Scholar 

  11. 11.

    Wang, J. et al. Nat. Genet 48, 768–776 (2016).

    CAS  Article  Google Scholar 

  12. 12.

    Ramaswamy, V. et al. Lancet Oncol. 14, 1200–1207 (2013).

    CAS  Article  Google Scholar 

  13. 13.

    O’Rourke, D.M. et al. Sci. Transl. Med. 9, eaaa0984. https://doi.org/10.1126/scitranslmed.aaa0984 (2017).

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Sheila K. Singh.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Qazi, M.A., Bakhshinyan, D. & Singh, S.K. Deciphering brain tumor heterogeneity, one cell at a time. Nat Med 25, 1474–1476 (2019). https://doi.org/10.1038/s41591-019-0605-1

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing