Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

CANCER

Deciphering brain tumor heterogeneity, one cell at a time

Nature Medicine volume 25, pages 1474–1476 (2019)Cite this article

Subjects

Single-cell RNA sequencing characterizes clonal dynamics and distinct cellular states contributing to intratumoral heterogeneity in glioblastoma and medulloblastoma.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Comprehensive profiling of intratumoral heterogeneity in aggressive brain cancers using scRNA-seq.

References

  1. Turajlic, S., Sottoriva, A., Graham, T. & Swanton, C. Nat. Rev. Genet. 20, 404–416 (2019).

    Article  CAS  Google Scholar 

  2. Suva, M. L. & Tirosh, I. Mol. Cell 75, 7–12 (2019).

    Article  CAS  Google Scholar 

  3. Neftel, C. et al. Cell 178, 835–849 (2019).

    Article  CAS  Google Scholar 

  4. Hovestadt, V. et al. Nature 572, 74–79 (2019).

    Article  CAS  Google Scholar 

  5. Stupp, R. et al. N. Engl. J. Med. 352, 987–996 (2005).

    Article  CAS  Google Scholar 

  6. Verhaak, R. G. et al. Cancer Cell 17, 98–110 (2010).

    Article  CAS  Google Scholar 

  7. Wang, Q. et al. Cancer Cell 32, 42–56 e46 (2017).

    Article  Google Scholar 

  8. Patel, A. P. et al. Science 344, 1396–1401 (2014).

    Article  CAS  Google Scholar 

  9. Vladoiu, M. C. et al. Nature 572, 67–73 (2019).

    Article  CAS  Google Scholar 

  10. Gao, R. et al. Nat. Commun. 8, 228 (2017).

    Article  Google Scholar 

  11. Wang, J. et al. Nat. Genet 48, 768–776 (2016).

    Article  CAS  Google Scholar 

  12. Ramaswamy, V. et al. Lancet Oncol. 14, 1200–1207 (2013).

    Article  CAS  Google Scholar 

  13. O’Rourke, D.M. et al. Sci. Transl. Med. 9, eaaa0984. https://doi.org/10.1126/scitranslmed.aaa0984 (2017).

    Article  Google Scholar 

Download references

Author information

Author notes

  1. These authors contributed equally: Maleeha A. Qazi, David Bakhshinyan.

Authors and Affiliations

  1. Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada

    Maleeha A. Qazi, David Bakhshinyan & Sheila K. Singh

  2. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada

    Maleeha A. Qazi, David Bakhshinyan & Sheila K. Singh

  3. Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada

    Sheila K. Singh

Authors
  1. Maleeha A. Qazi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David Bakhshinyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sheila K. Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sheila K. Singh.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Qazi, M.A., Bakhshinyan, D. & Singh, S.K. Deciphering brain tumor heterogeneity, one cell at a time. Nat Med 25, 1474–1476 (2019). https://doi.org/10.1038/s41591-019-0605-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41591-019-0605-1

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer