PUBLIC HEALTH

The benefits and risks of mass antibiotic use for reducing child mortality

Mass administration of azithromycin to young children at risk of dying could reduce harmful intestinal pathogenic bacteria and impact survival, but also increase antibiotic resistance.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1

References

  1. 1.

    Doan. T. et al. Nat. Med. https://doi.org/10.1038/s41591-019-0533-0 (2019).

  2. 2.

    Porco, T. C. et al. J. Am. Med. Assoc. 302, 962–968 (2009).

    CAS  Article  Google Scholar 

  3. 3.

    Keenan, J. D. et al. N. Engl. J. Med. 378, 1583–1592 (2018).

    CAS  Article  Google Scholar 

  4. 4.

    Oldenburg, C. E. et al. Am. J. Trop. Med. Hyg. 100, 691–695 (2019).

    Article  Google Scholar 

  5. 5.

    Arzika, A. M. et al. PLoS Med. 16, e1002835 (2019).

    Article  Google Scholar 

  6. 6.

    Chandramohan, D. et al. N. Engl. J. Med. 380, 2197–2206 (2019).

    Article  Google Scholar 

  7. 7.

    Doan, T. et al. Open Forum Infect. Dis. 5, ofy182, https://doi.org/10.1093/ofid/ofy182 (2018).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  8. 8.

    Liu, J. et al. Lancet 388, 1291–1301 (2016).

    CAS  Article  Google Scholar 

  9. 9.

    Rogawski, E.T. et al. Lancet Glob. Health 6, e1319–e1328.

  10. 10.

    Whitty, C. J., Glasgow, K. W., Sadiq, S. T., Mabey, D. C. & Bailey, R. Pediatr. Infect. Dis. J. 18, 955–958 (1999).

    CAS  Article  Google Scholar 

  11. 11.

    Keenan, J. D. et al. PLoS Negl. Trop. Dis. 13, e0007442 (2019).

    Article  Google Scholar 

  12. 12.

    Doan, T. et al. N. Engl. J. Med. 380, 2271–2273 (2019).

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Zulfiqar A. Bhutta.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bhutta, Z.A. The benefits and risks of mass antibiotic use for reducing child mortality. Nat Med 25, 1332–1334 (2019). https://doi.org/10.1038/s41591-019-0576-2

Download citation

Further reading