Cardiovascular disease

A protective smooth muscle cell transition in atherosclerosis

TCF21, a gene associated with coronary heart disease, promotes plaque stability and reduces clinical events by enhancing smooth muscle cell phenotype modulation into “fibromyocytes” in atherosclerosis.

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Fig. 1: The role of TCF21 in atherosclerosis.

References

  1. 1.

    Wong, D., Turner, A. W. & Miller, C. L. Arterioscler. Thromb. Vasc. Biol. 39, 1006–1017 (2019).

    CAS  Article  Google Scholar 

  2. 2.

    Bennett, M. R., Sinha, S. & Owens, G. K. Circ. Res. 118, 692–702 (2016).

    CAS  Article  Google Scholar 

  3. 3.

    Wirka, R. C. et al. Nat. Med. https://doi.org/10.1038/s41591-019-0512-5 (2019).

    CAS  Article  Google Scholar 

  4. 4.

    Acharya, A. et al. Development 139, 2139–2149 (2012).

    CAS  Article  Google Scholar 

  5. 5.

    Schunkert, H. et al. Nat. Genet. 43, 333–338 (2011).

    CAS  Article  Google Scholar 

  6. 6.

    Feil, S. et al. Circ. Res. 115, 662–667 (2014).

    CAS  Article  Google Scholar 

  7. 7.

    Shankman, L. S. et al. Nat. Med. 21, 628–637 (2015).

    CAS  Article  Google Scholar 

  8. 8.

    Chappell, J. et al. Circ. Res. 119, 1313–1323 (2016).

    CAS  Article  Google Scholar 

  9. 9.

    Daugherty, A. et al. Arterioscler. Thromb. Vasc. Biol. 37, e131–e157 (2017).

    CAS  PubMed  Google Scholar 

  10. 10.

    Zhang, H. & Reilly, M. P. Circ. Res. 123, 1106–1108 (2018).

    CAS  Article  Google Scholar 

  11. 11.

    Dobnikar, L. et al. Nat. Commun. 9, 4567 (2018).

    Article  Google Scholar 

  12. 12.

    Gomez, D. & Owens, G. K. Cardiovasc. Res. 95, 156–164 (2012).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Muredach P. Reilly.

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Pan, H., Reilly, M.P. A protective smooth muscle cell transition in atherosclerosis. Nat Med 25, 1194–1195 (2019). https://doi.org/10.1038/s41591-019-0541-0

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