Infectious disease

Lessons about early neurodevelopment in children exposed to ZIKV in utero

Infants with congenital Zika virus infection are at risk for multiple abnormalities related to impairment in neurodevelopment. Although some findings apparent at birth may resolve with time, infants with no abnormalities apparent at birth may develop problems in early childhood.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Children with in utero Zika exposure may experience neurodevelopmental, eye, and hearing abnormalities that can revert.


  1. 1.

    Franca, G. V. et al. Lancet 388, 891–897 (2016).

    Article  Google Scholar 

  2. 2.

    Moore, C. A. et al. JAMA Pediatr 171, 288–295 (2017).

    Article  Google Scholar 

  3. 3.

    Adebanjo, T. et al. MMWR Morb. Mortal. Wkly Rep. 66, 1089–1099 (2017).

    Article  Google Scholar 

  4. 4.

    Honein, M. A. et al. JAMA 317, 59–68 (2017).

    Article  Google Scholar 

  5. 5.

    Nielsen-Saines, K. et al. Nat. Med. (2019).

    CAS  Article  Google Scholar 

  6. 6.

    Brasil, P. et al. N. Engl. J. Med. 375, 2321–2334 (2016).

    Article  Google Scholar 

  7. 7.

    Shapiro-Mendoza, C. K. et al. MMWR Morb. Mortal. Wkly Rep. 66, 615–621 (2017).

    Article  Google Scholar 

  8. 8.

    Hoen, B. et al. N. Engl. J. Med. 378, 985–994 (2018).

    Article  Google Scholar 

  9. 9.

    Ho, C. Y. et al. Ann. Neurol. 82, 121–127 (2017).

    CAS  Article  Google Scholar 

  10. 10.

    Rice, M. E. et al. MMWR Morb. Mortal. Wkly Rep. 67, 858–867 (2018).

    Article  Google Scholar 

  11. 11.

    Duffy, M. R. et al. N. Engl. J. Med. 360, 2536–2543 (2009).

    CAS  Article  Google Scholar 

  12. 12.

    Halai, U. A. et al. Clin. Infect. Dis. 65, 877–883 (2017).

    Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to William J. Muller.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Muller, W.J., Mulkey, S.B. Lessons about early neurodevelopment in children exposed to ZIKV in utero. Nat Med 25, 1192–1193 (2019).

Download citation


Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing