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Rethinking herd immunity

The global rise of ‘vaccine hesitancy’ is changing the landscape of disease transmission.

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  1. Sugerman, D. E. et al. Pediatrics 125, 747–755 (2010).

    Article  Google Scholar 

  2. Centers for Disease Control and Prevention (CDC). MMWR Morb. Mortal. Wkly. Rep. 57, 203–206 (2008).

  3. World Health Organization. Ten threats to global health in 2019. (accessed 2 April 2019).

  4. Cairns, K. L., Nandy, R. & Grais, R. F. Emerg. Themes Epidemiol. 7, 4 (2010).

    Article  Google Scholar 

  5. World Health Organization. Measles. (2019).

  6. Richard, J. L. & Spicher, V. M. Eurosurveillance 14, 19443 (2009).

    PubMed  Google Scholar 

  7. Salathé, M. & Bonhoeffer, S. J. R. Soc. Interface 29, 1505–1508 (2008).

    Article  Google Scholar 

  8. Gavi. Democratic Republic of Congo launches major vaccine drive. (2018).

  9. UNICEF. Pakistan. (accessed 2 April 2019).

  10. How the CIA’s fake vaccination campaign endangers us all. Scientific American (2013).

  11. Broniatowski, D. A. et al. Am. J. Public Health 108, 1378–1384 (2018).

    Article  Google Scholar 

  12. Salathé, M. & Khandelwal, S. PLoS Comput. Biol. 7, e1002199 (2011).

    Article  Google Scholar 

  13. Mosser, J. F. et al. Lancet 393, 1843–1855 (2019).

    Article  Google Scholar 

  14. Olive, J. K., Hotez, P. J., Damania, A. & Nolan, M. S. PLoS Med. 15, e1002578 (2018).

    Article  Google Scholar 

  15. Mohanty, S. et al. Pediatrics 142, e20181051 (2018).

    Article  Google Scholar 

  16. Gostin, L. O., Ratzan, S. C. & Bloom, B. R. JAMA (2019).

    Article  Google Scholar 

Download references

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Correspondence to Lynne Peeples.

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Peeples, L. Rethinking herd immunity. Nat Med 25, 1178–1180 (2019).

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