Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

IMMUNOTHERAPY

Programmable bacteria as cancer therapy

Nature Medicine volume 25, pages 1030–1031 (2019)Cite this article

Subjects

Quorum-sensing bacteria can deliver a nanobody targeting the ‘don’t eat me’ ligand CD47 to tumors that results in systemic anti-tumor immunity-induced regression in mice.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Inducing systemic anti-tumor immunity with quorum-sensing bacteria carrying nanobodies.

References

  1. Starnes, C. O. Nature 357, 11–12 (1992).

    Article  CAS  Google Scholar 

  2. Chowdhury, S. et al. Nat. Med. https://doi.org/10.1038/s41591-019-0498-z (2019).

  3. Ingram, J. R., Schmidt, F. I. & Ploegh, H. L. Annu. Rev. Immunol. 36, 695–715 (2018).

    Article  CAS  Google Scholar 

  4. Sockolosky, J. T. et al. Proc. Natl Acad. Sci. USA 113, E2646–E2654 (2016).

    Article  CAS  Google Scholar 

  5. Jaiswal, S. et al. Cell 138, 271–285 (2009).

    Article  CAS  Google Scholar 

  6. Weiskopf, K. Eur. J. Cancer 76, 100–109 (2017).

    Article  CAS  Google Scholar 

  7. Weiskopf, K. et al. Science 341, 88–91 (2013).

    Article  CAS  Google Scholar 

  8. Advani, R. et al. N. Engl. J. Med. 379, 1711–1721 (2018).

    Article  CAS  Google Scholar 

  9. Ingram, J. R. et al. Proc. Natl Acad. Sci. USA 114, 10184–10189 (2017).

    Article  CAS  Google Scholar 

  10. Liu, X. et al. Nat. Med. 21, 1209–1215 (2015).

    Article  CAS  Google Scholar 

  11. Xu, M. M. et al. Immunity 47, 363–373.e365 (2017).

    Article  CAS  Google Scholar 

  12. Silva, D. A. et al. Nature 565, 186–191 (2019).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA

    Michael Dougan

  2. Department of Medicine, Harvard Medical School, Boston, MA, USA

    Michael Dougan

  3. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA

    Stephanie K. Dougan

  4. Department of Immunology, Harvard Medical School, Boston, MA, USA

    Stephanie K. Dougan

Authors
  1. Michael Dougan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephanie K. Dougan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stephanie K. Dougan.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dougan, M., Dougan, S.K. Programmable bacteria as cancer therapy. Nat Med 25, 1030–1031 (2019). https://doi.org/10.1038/s41591-019-0513-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41591-019-0513-4

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer