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IMMUNOTHERAPY

Programmable bacteria as cancer therapy

Quorum-sensing bacteria can deliver a nanobody targeting the ‘don’t eat me’ ligand CD47 to tumors that results in systemic anti-tumor immunity-induced regression in mice.

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Fig. 1: Inducing systemic anti-tumor immunity with quorum-sensing bacteria carrying nanobodies.

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Correspondence to Stephanie K. Dougan.

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Dougan, M., Dougan, S.K. Programmable bacteria as cancer therapy. Nat Med 25, 1030–1031 (2019). https://doi.org/10.1038/s41591-019-0513-4

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