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Combining checkpoint inhibition and targeted therapy in melanoma

The combination of BRAF and MEK inhibition and anti-PD-1 is tolerable and has promising efficacy, which warrants further investigation into its use as melanoma therapy.

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Fig. 1: Combined checkpoint inhibition and targeted therapy for melanoma.


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Correspondence to Christian U. Blank.

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Competing interests

E.A.R. received travel support from MSD and NanoString. C.U.B. reports personal fees as a consultant advisor for Bristol-Myers Squibb, Merck Sharpe Dohme, Roche, Novartis, Lilly, Pfizer, GlaxoSmithKline, GenMab and Pierre Fabre and has received research grants from Bristol-Myers Squibb, Novartis, and NanoString, all paid to the institution (Netherlands Cancer Institute).

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Rozeman, E.A., Blank, C.U. Combining checkpoint inhibition and targeted therapy in melanoma. Nat Med 25, 879–882 (2019).

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