Extended Data Fig. 1: The deviation from HWE with age. | Nature Medicine

Extended Data Fig. 1: The deviation from HWE with age.

From: CCR5-∆32 is deleterious in the homozygous state in humans

Extended Data Fig. 1

a, The observed deviation using age at recruitment estimated. Each dot represents one age group. The grey error bars show the 95% confidence intervals estimated from bootstrap the genotypes of individuals recruited at each age 1000 times. The sample size used for each error bar ranges from 15191 to 100117 with a mean of 65479. b, The predicted deviation from HWE using the corrected survival probability. A total of 395704 samples are used. The observed and predicted values are significantly correlated (Spearman’s correlation coefficient ρ= 0.67, P= 1.4 × 10−4).

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