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CANCER THERAPY

Molecular profiling in precision medicine oncology

Three innovative precision medicine studies show the utility of evidence beyond that from tumor DNA sequencing to guide therapy in patients with cancer.

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Fig. 1: New concepts evaluated in the I-PREDICT, TARGET and WINTHER studies.

References

  1. Yates, L. R. Ann. Oncol. 29, 30–35 (2018).

    Article  CAS  Google Scholar 

  2. Le, D. T. New Engl. J. Med. 372, 2509–2520 (2015).

    Article  CAS  Google Scholar 

  3. Drilon, A. New Engl. J. Med. 378, 731–739 (2018).

    Article  CAS  Google Scholar 

  4. Rothwell, D. G. Nat. Med. https://doi.org/10.1038/s41591-019-0380-z (2019).

  5. Sicklick, J. K. Nat. Med. https://doi.org/10.1038/s41591-019-0407-5 (2019).

  6. Rodon, J. Nat. Med. https://doi.org/10.1038/s41591-019-0424-4 (2019).

  7. von Hoff, D. D. J. Clin. Oncol. 28, 4877–4883 (2010).

    Article  Google Scholar 

  8. Stockley, T. L. Genome Med. 8, 109 (2016).

    Article  Google Scholar 

  9. Le Tourneau, C. Lancet Oncol. 16, 1324–1334 (2015).

    Article  Google Scholar 

  10. Belin, L. Ann. Oncol. 28, 590–596 (2017).

    CAS  PubMed  Google Scholar 

  11. Massard, C. Cancer Disco. 7, 586–595 (2017).

    Article  CAS  Google Scholar 

Download references

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All authors contributed to the writing of the manuscript.

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Correspondence to Christophe Le Tourneau.

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Competing interests

C.L.T. has received consultant fees from Merck Serono, Merck & Co., Bristol-Myers Squibb, Amgen, Novartis, GlaxoSmithKline and Roche.

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Le Tourneau, C., Borcoman, E. & Kamal, M. Molecular profiling in precision medicine oncology. Nat Med 25, 711–712 (2019). https://doi.org/10.1038/s41591-019-0442-2

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