PLSDA was performed utilizing antigen-specific antibody levels, Fc effector functions and IgG glycosylation (total number of initial features = 216). a, The scores plot (left) shows the IFN-γ-negative and IFN-γ-positive profiles for each individual (dots). b, The loadings plot (right in a) shows that 16 antibody features separated each group with 100% calibration and 100% tenfold cross-validation accuracy. LV1 captures 19.1% of the X variance and 39.9% of the Y variance. Discriminatory features are depicted in a variable importance plot using the projection (VIP) scores that represent the weight of the selected variables in contributing to the overall separation between the groups (b) with features associated with ‘resisters’ to the left and IGRA/TST-positive LTBI individuals to the right.