A (delayed) history of the brain lymphatic system


It has been only recently that scientists come to realize the existence of a lymphatic system within the central nervous system. However, an Italian anatomist had already found and described the system in fine detail over 200 years ago.

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Fig. 1: Portrait of Paolo Mascagni by S. Ricci; stipple engraving by G. Buccinelli after R. Focosi after S. Ricci.
Fig. 2: Figure from the Vasorum Lymphaticorum Corporis Humani Historia et Ichnographia (1787).


  1. 1.

    Louveau, A. et al. Nature 523, 337–341 (2015).

    CAS  Article  Google Scholar 

  2. 2.

    Aspelund, A. et al. J. Exp. Med. 212, 991–999 (2015).

    CAS  Article  Google Scholar 

  3. 3.

    Da Mesquita, S. et al. Nature 560, 185–191 (2018).

    CAS  Article  Google Scholar 

  4. 4.

    Louveau, A. et al. Nat. Neurosci. 21, 1380–1391 (2018).

    CAS  Article  Google Scholar 

  5. 5.

    Da Mesquita, S. et al. Neuron 100, 375–388 (2018).

    CAS  Article  Google Scholar 

  6. 6.

    Absinta, M. et al. eLife 6, e29738 (2017).

    Article  Google Scholar 

  7. 7.

    Arieti, S. Dizionario Biografico degli Italiani Vol. 71. Mascagni, Paolo (Istituto Della Enciclopedia Italiana, 2008).

  8. 8.

    Mascagni, P., & Ciro, S. Vasorum lymphaticorum Corporis Humani Historia et Ichnographia. Auctore Paulo Mascagni in Regio Senarum Lyceo Publico Anatomes Professore (Ex typographia Pazzini Carli, 1787).

  9. 9.

    Lukić, I. K., Glunčić, V., Ivkić, G., Hubenstorf, M. & Marušić, A. Lancet 362, 2110–2113 (2003).

    Article  Google Scholar 

  10. 10.

    Di Matteo, B. et al. Clin. Orthop. Relat. Res. 473, 783–788 (2015).

    Article  Google Scholar 

  11. 11.

    Catani, M. & Sandrone, S. Brain Renaissance: From Vesalius to Modern Neuroscience (Oxford University Press, 2015).

  12. 12.

    Brierley, J. B. & Field, E. J. J. Anat. 82, 153–166 (1948).

    PubMed  PubMed Central  Google Scholar 

  13. 13.

    Lecco, V. Arch. Ital. Otol. Rinol. Laringol. 64, 287–296 (1953).

    CAS  PubMed  Google Scholar 

  14. 14.

    Földi, M. et al. J. Vasc. Res. 5, 250–262 (1968).

    Article  Google Scholar 

  15. 15.

    Andres, K. H., von Düring, M., Muszynski, K. & Schmidt, R. F. Anat. Embryol. 175, 289–301 (1987).

    CAS  Article  Google Scholar 

  16. 16.

    Cserr, H. F., Cooper, D. N., Suri, P. K. & Patlak, C. S. Am. J. Physiol. Renal. Physiol. 240, F319–F328 (1981).

    CAS  Article  Google Scholar 

  17. 17.

    Kida, S., Pantazis, A. & Weller, R. O. Neuropath. Appl. Neurobiol. 19, 480–488 (1993).

    CAS  Article  Google Scholar 

  18. 18.

    Li, J., Zhou, J. & Shi, Y. Ann. Anat. 178, 259–261 (1996).

    CAS  Article  Google Scholar 

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Correspondence to Stefano Sandrone.

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S.S. receives royalties from Oxford University Press (United States) for Brain Renaissance (2015). J.K. is a scientific co-founder and a scientific board member of Ariya Therapeutics, Inc. (PureTech Health).

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Sandrone, S., Moreno-Zambrano, D., Kipnis, J. et al. A (delayed) history of the brain lymphatic system. Nat Med 25, 538–540 (2019). https://doi.org/10.1038/s41591-019-0417-3

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