Divergent effects of lipids on stroke

A large study provides causal evidence of the opposing effects of plasma low-density lipoprotein (LDL) levels on ischemic and hemorrhagic stroke in a Chinese population and suggests there is a a net benefit associated with LDL lowering.

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Fig. 1: The link between plasma LDL and stroke.


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Correspondence to Mitchell S. V. Elkind.

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Competing interests

M.S.V.E. discloses receiving personal compensation for serving as an expert witness for Merck/Organon and Auxilium; honoraria for writing chapters on stroke for UpToDate; and research support but no personal compensation for a federally funded clinical trial related to stroke prevention from both the BMS-Pfizer Alliance for Eliquis and Roche; and serving as an unpaid national board member of the American Heart Association. N.S.P. has no competing interests.

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Parikh, N.S., Elkind, M.S.V. Divergent effects of lipids on stroke. Nat Med 25, 543–544 (2019).

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