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Adding to the checkpoint blockade armamentarium

Antitumor immunity can be enhanced by blocking NKG2A, an inhibitory receptor expressed on natural killer and T cells.

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Fig. 1: Inhibition of NKG2A enhances cancer-immune interactions.


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Correspondence to Alexandra Snyder.

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Competing interests

A.S. is an employee of and owns stock in Merck. M.D.H. receives research funding from Bristol-Myers Squibb; is a paid consultant to Merck, Bristol-Myers Squibb, AstraZeneca, Genentech/Roche, Janssen, Nektar, Syndax, Mirati, and Shattuck Labs; receives travel support and honoraria from AztraZeneca and BMS; and has filed a patent related to the use of tumor mutation burden to predict response to immunotherapy (PCT/US2015/062208), which has received licensing fees from PGDx.

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Hellmann, M.D., Snyder, A. Adding to the checkpoint blockade armamentarium. Nat Med 25, 203–205 (2019).

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