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Protection against tuberculosis by mucosal BCG administration

Vaccination with the tuberculosis (TB) vaccine Bacillus Calmette–Guérin (BCG) into the lungs of Rhesus macaques induces specific, local immune responses that delay infection in some animals and completely prevent it in others while protecting against TB disease.

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Fig. 1: Vaccine-induced protection against Mtb infection and TB is dependent on mycobacteria-specific immune responses at the site of infection.


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Correspondence to Thomas J. Scriba.

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Scriba, T.J., Nemes, E. Protection against tuberculosis by mucosal BCG administration. Nat Med 25, 199–201 (2019).

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