News & Views | Published:

NEURODEGENERATION

An exercise-induced messenger boosts memory in Alzheimer’s disease

Nature Medicinevolume 25pages2021 (2019) | Download Citation

An exercise-linked hormone, FNDC5/irisin, mediates the benefit of exercise in Alzheimer’s disease models by enhancing synaptic plasticity and memory.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Alzheimer’s Association. Alzheimer’s & Dementia 14, 367–429 (2018).

  2. 2.

    Arnold, S. E. et al. Nat. Rev. Neurol. 14, 168–181 (2018).

  3. 3.

    Maliszewska-Cyna, E., Lynch, M., Oore, J. J., Nagy, P. M. & Aubert, I. Curr. Alzheimer Res. 14, 47–60 (2017).

  4. 4.

    Lourenco, M. V. et al. Nat. Med. http://doi.org/10.1038/s41591-018-0275-4 (2018).

  5. 5.

    Walsh, D. M. et al. Nature 416, 535–539 (2002).

  6. 6.

    Bostrom, P. et al. Nature 481, 463–468 (2012).

  7. 7.

    Polyzos, S. A. et al. Endocrine 59, 260–274 (2018).

  8. 8.

    Zhang, J. & Zhang, W. Biomol. Concepts 7, 253–258 (2016).

  9. 9.

    Benito, E. & Barco, A. Trends Neurosci. 33, 230–240 (2010).

  10. 10.

    Moon, H. Y. et al. Cell Metab. 24, 332–340 (2016).

  11. 11.

    Sampson, T. R.et al. Cell 167, 1469–1480 e1412 (2016).

  12. 12.

    Rothhammer, V. et al. Nature 557, 724–728 (2018).

Download references

Author information

Affiliations

  1. Gladstone Institutes, Department of Neurology, University of California San Francisco, San Francisco CA, USA

    • Xu Chen
    •  & Li Gan
  2. Helen and Robert Appel Alzheimer’s Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA

    • Li Gan

Authors

  1. Search for Xu Chen in:

  2. Search for Li Gan in:

Competing interests

L.G is a cofounder of Aeton Therapeutics, Inc.

Corresponding author

Correspondence to Li Gan.

About this article

Publication history

Published

Issue Date

DOI

https://doi.org/10.1038/s41591-018-0311-4

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing