METABOLIC DISEASES

Metformin action through the microbiome and bile acids

Metformin functions through a gut microbiome–bile acid–farnesoid X receptor axis to lower glucose in type 2 diabetes, revealing a new therapeutic target in this disease.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Metformin acts through changes in gut B. fragilis and bile acid signaling.

References

  1. 1.

    Sterne, J. Maroc Med. 36, 1295–1296 (1957).

  2. 2.

    Karlsson, F. H. et al. Nature 498, 99 (2013).

  3. 3.

    Napolitano, A. et al. PLoS ONE 9, e100778 (2014).

  4. 4.

    Sun, L. et al. Nat. Med. https://doi.org/10.1038/s41591-018-0222-4 (2018).

  5. 5.

    Chow, M. D., Lee, Y.-H. & Guo, G. L. Mol. Aspects Med. 56, 34–44 (2017).

  6. 6.

    Chiang, J. Y. L. et al. Dig. Dis. 35, 241–245 (2017).

  7. 7.

    Foretz, M. et al. J. Clin. Invest. 120, 2355–2369 (2010).

  8. 8.

    Mueller, M. et al. J. Hepatol. 62, 1398–1404 (2015).

  9. 9.

    Lindor, K. D. et al. Hepatology 39, 770–778 (2004).

  10. 10.

    Fang, S. et al. Nat. Med. 21, 159–165 (2015).

  11. 11.

    Pathak, P. et al. Hepatology 68, 1574–1588 (2018).

Download references

Author information

Correspondence to Grace L. Guo.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Guo, G.L., Xie, W. Metformin action through the microbiome and bile acids. Nat Med 24, 1789–1790 (2018). https://doi.org/10.1038/s41591-018-0273-6

Download citation

Further reading