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DISEASE GENETICS

Linking brain tumors and epileptic seizures

Mutationally activated BRAF-V600E influences the behavior of different types of cells in the brain and leads to promotion of seizures as well as brain tumors, indicating how both can be pharmacologically targeted in the clinic.

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Fig. 1: The role of BRAF-V600E signaling and REST in GG-associated intractable epilepsy.

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Correspondence to Jean M. Mulcahy Levy or Martin McMahon.

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Mulcahy Levy, J.M., McMahon, M. Linking brain tumors and epileptic seizures. Nat Med 24, 1638–1639 (2018). https://doi.org/10.1038/s41591-018-0249-6

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