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INFECTIOUS DISEASE

A stratified approach to tuberculosis treatment

Nature Medicine volume 24, pages 1639–1641 (2018)Cite this article

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Stratifying tuberculosis (TB) disease into minimal, moderate or severe disease may allow treatment duration to be tailored to disease severity. Minimal poor adherence is associated with poor treatment outcomes.

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Fig. 1: Stratified medicine strategy for TB.

References

  1. World Health Organization. Guidelines for Treatment of Drug-Susceptible Tuberculosis and Patient Care, 2017 Update (WHO, Geneva, 2017).

  2. Savic, et al. Nat. Med. https://doi.org/10.1038/s41591-018-0224-2 (2018).

  3. Gillespie, S. H. et al. N. Engl. J. Med. 371, 1577–1587 (2014).

  4. Merle, C. S. et al. N. Engl. J. Med. 371, 1588–1598 (2014).

  5. Jindani, A. et al. N. Engl. J. Med. 371, 1599–1608 (2014).

  6. Kendall, E. A. et al. PLoS Med. 14, e1002202 (2017).

  7. World Health Organization. Global Tuberculosis Report 2018 (WHO, Geneva, 2018).

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Authors and Affiliations

  1. Aurum Institute, Johannesburg, South Africa

    Gavin J. Churchyard

  2. School of Public Health, University of Witwatersrand, Johannesburg, South Africa

    Gavin J. Churchyard

  3. Advancing Care and Treatment for TB/HIV, South African Medical Research Council, Johannesburg, South Africa

    Gavin J. Churchyard

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  1. Gavin J. Churchyard
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Correspondence to Gavin J. Churchyard.

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Churchyard, G.J. A stratified approach to tuberculosis treatment. Nat Med 24, 1639–1641 (2018). https://doi.org/10.1038/s41591-018-0244-y

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