Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Rules of engagement in the gut microbiome

This article has been updated

In humans, niche-specific gastrointestinal microbiomes influence the colonization success of probiotic microbes. Microbiome reconstitution following antimicrobial perturbation is most successful using preperturbation autofecal microbial transplant.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: The effect of auto-FMT and probiotics on microbiome colonization.

Change history

  • 12 November 2018

    In the version of this article that was originally published, the names of the authors appeared at the beginning of the standfirst. This was an error, and their names have now been removed from the standfirst.


  1. Macpherson, A. J. & Harris, N. L. Nat. Rev. Immunol. 4, 478–485 (2004).

  2. Trompette, A. et al. Nat. Med. 20, 159–166 (2014).

  3. Fonseca, W. et al. Mucosal Immunol. 10, 1569–1580 (2017).

  4. Wang, Z. et al. Nature 472, 57–63 (2011).

  5. Hsiao, E. Y. et al. Cell 155, 1451–1463 (2013).

  6. Fujimura, K. E. et al. Proc. Natl Acad. Sci. USA. 111, 805–810 (2014).

  7. Hoyles, L. et al. Nat. Med. 24, 1070–1080 (2018).

  8. Metchnikoff, E. The Prolongation of Life; Optimistic Studies (English Translation) (New York Putnam, New York, 1910).

  9. Suez, J. et al. Cell 174, 1406–1423. (2018).

  10. Zmora, N. et al. Cell 174, 1388–1405.(2018).

  11. Fujimura, K. E. et al. Nat. Med. 22, 1187–1191 (2016).

  12. Arrieta, M.-C. et al. Sci. Transl. Med. 7, 307ra152 (2015).

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Susan V. Lynch.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Rackaityte, E., Lynch, S.V. Rules of engagement in the gut microbiome. Nat Med 24, 1642–1644 (2018).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing